Dr Pistor and The Reflex Theory of Mesotherapy


After completing his studies at the Faculty of Medicine in Paris, Doctor Michel Pistor (1924–2003) specialised in general medicine in a small country village.

When treating pain syndromes and soft tissue injuries with oral medication, he recognised the associated problems of the caustic effect of the large doses required and with reoccuring trauma, starting again at stage one of the therapy.

Dr Pistor conceived that certain conditions may be best treated by introducing small amounts of medicine directly at the site of the problem, and in 1952 he invented the simple but revolutionary technique – Mesotherapy.

The Larousse dictionary gives this definition:
a therapeutic procedure that consists of injecting a minimal dose of medication, at a slight depth by needles at the closest point possible to the origin of the pain or illness.
Practitioners of mesotherapy know all too well that it’s an effective treatment option for many aesthetic concerns of clients but in fact, there are a number of theories as to the mechanics of why it actually works and is so successful.

Dr Pistor proposed his Reflex Theory. He believed that the results obtained by administering small doses of medicine to regional areas of the body, could not be sufficiently explained simply by their pharmacological action when the cause of the pathology is located deep in the organs.

Dr Pistor proposed that the skin is actually a projection of different internal locations of deep organs which can be mapped out, just like in acupuncture.

According to this Reflex theory of mesotherapy, there is the inhibitory stimuli which originates at the dermal level. This can be mechanical, which is provoked by the needle, and physiochemical-pharmacological, due to the medicine administered and its action.

This stimuli interrupts certain pathways in the brain, the medullar (inner core of certain organs) and visceral (internal organs of the body within the chest). The stimuli work by obstructing flux (movement of substances) in the nervous system.

According to this concept, small amounts of medicine, directly targeted at the tissue local to the problem, infrequently (once or twice a week) can achieve significant results. As Dr Pistor said, “ little, rarely and in the right place.”


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